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A new study found approximately 25 percent of the women who should take hormone-blocking therapies as part of their breast cancer treatment either do not start or do not complete the five-year course.
University of Michigan Comprehensive Cancer Center researchers found that about 11 percent never initiated the treatments and 15 percent stopped taking it early. . The majority cited side effects or fears about possible side effects as their reason for not undertaking the recommended therapy.
"We need to develop better ways of supporting women through this therapy," concluded lead study author Christopher Friese, Ph.D., R.N., assistant professor at the University of Michigan School of Nursing. “If guidelines begin to shift so that some women at high risk of breast cancer recurring need ten years of endocrine therapy, then the number of women who persist with treatment will likely worsen."
Five years of daily tamoxifen or aromatase inhibitors -- two types of endocrine therapy that are taken as a pill -- is recommended for many women whose breast cancer expresses the hormones estrogen or progesterone. The drugs have been shown to reduce cancer recurrence and increase survival. Recent studies suggest there may be even more benefit for some women to continue this therapy for 10 years.
Many women experience menopause-like symptoms such as hot flashes or vaginal dryness, and both types of drugs, more commonly the aromatase inhibitors, can cause joint pains.
Women who expressed more worry about their cancer recurring were more likely to complete endocrine therapy, as were women who already took medication regularly.
Women who reported receiving less information about endocrine therapy were less likely to begin taking it, suggesting that doctors need to address patient education before treatment starts. Women who saw a breast surgeon as their primary follow-up, rather than a medical oncologist, were also less likely to begin endocrine therapy.
“It was particularly interesting that greater fear of recurrence was associated in our patient sample with greater adherence to endocrine therapy,” said senior study author Jennifer J. Griggs, M.D., M.P.H., professor of internal medicine at the U-M Medical School and a medical oncologist who sees patients with breast cancer at the U-M Comprehensive Cancer Center.
“We don’t want our patients living under a cloud of fear, so we need to develop creative ways to both reassure and motivate them. This means providing better education about the importance of staying on these medications and partnering with primary care and cancer doctors to help patients manage symptoms,” Griggs added.
Results from this study were published earlier this month in Breast Cancer Research and Treatment.