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Help Fund Research

Targeted research is our best opportunity to beat breast cancer forever.

Every moment counts in the fight against breast cancer and in the search for a cure. Now, The Breast Cancer Site has found one more way to help. We're working with the Mayo Clinic and with the University of Michigan to forward research and understanding into the biology of breast cancer with the ultimate goal of defeating it forever. We hope to discover new ways to predict, prevent, diagnose, and treat breast cancer, transforming the lives of breast cancer patients today and in the future.


The University of Michigan's Comprehensive Cancer Center

www.mcancer.org

Cancer occurs when a genetic mutation in a cell's DNA causes it to multiply rapidly without control. Current treatments, including radiation, surgery, and chemotherapy, target healthy cells and cancer cells indiscriminately.

Dr. Arul Chinnaiyan at The University of Michigan is doing research that could change all that. Rather than focusing on where in the body the cancer is located, Dr. Chinnaiyan is at the forefront of groundbreaking research to understand cancer on a genetic and molecular basis, targeting the mutations that cause the cancer for detection and treatment. His research team is working toward the swift and systematic genetic sequencing of cancerous material from individual patients, with the goal of identifying more effective and precise treatments.

Imagine a world in which we fight cancer on a targeted, individualized basis, instead of a one-size-fits all treatment. That is the world The Breast Cancer Site and The University of Michigan are working toward.


The Mayo Clinic

www.mayoclinic.org

Mayo Clinic is the first and largest integrated group practice in the world. Doctors from every medical specialty work together to care for patients, joined by common systems and a philosophy of "the needs of the patient come first." Nearly 3,500 physicians and scientists and more than 48,000 allied health staff work at the sites in Rochester, Minn., Jacksonville, Fla., and Arizona. Collectively, three clinic locations treat more than half a million people each year.

About The Endowed Fund

Once fully funded, interest earned from the endowed fund for breast cancer research will be used to pay the salary of a breast cancer researcher at Mayo Clinic. The Breast Cancer Site Endowed Fund for Breast Cancer Research at Mayo Clinic will fund breast cancer research in perpetuity. Your tax-deductible donation through our secure online store is matched by Mayo Clinic up to $250,000, so your contribution is doubled at no extra cost to you. Click here to learn more: Endowed Fund for The Breast Cancer Site Researcher at Mayo Clinic.

The Mayo endowment is a pool of permanent funds whose purpose is to provide a perpetual stream of annual financial support for Mayo Clinic. The Mayo endowment traces its roots to a series of large gifts made by Clinic founders, Drs. William J. and Charles H. Mayo, between 1915 and 1934. During this period, the brothers set up the charitable not-for-profit organization now known as Mayo Clinic, to which they contributed the assets of their then privately-owned practice, and gave large personal sums to help sustain its research and education programs.

Breakthrough Research Done

Paul Haluska M.D., Ph.D, an oncologist at Mayo Clinic in Rochester, Minn, and Matthew P. Goetz, M.D., a breast cancer oncologist at Mayo Clinic, are past recipients of The Breast Cancer Site Research Scholar Award. Their work is creating a better understanding of treatments and how to more effectively help women with breast cancer.

Tamoxifen, a drug prescribed to breast cancer patients following surgical treatment, is successfully metabolized by the body using a gene called CYP2D6, which converts the drug into an active agent called endoxifen. When a team of Mayo scientists discovered that tamoxifen was less effective in women who inherited a genetic form of the CYP2D6 gene that did not properly metabolize the drug, the scientific community was skeptical.

Dr. Goetz and a second research team has not only consolidated their findings in the lab, but also discovered that endoxifen works by an entirely unexpected molecular mechanism. Dr. Goetz concluded that women with variations on the CYP2D6 gene, as well as those taking anti-depressants with tamoxifen, would have problems metabolizing tamoxifen. The group's work has led to a recent FDA recommendation to change the label of tamoxifen to incorporate the importance of genetic and drug-induced variation in CYP2D6.

Dr. Goetz's work is performed in collaboration with the laboratory of Matthew Ames, Ph.D., chair of the Department of Molecular Pharmacology and Experimental Therapeutics at Mayo Clinic. Additional key collaborators at Mayo Clinic are James Ingle, M.D., Richard Weinshilboum, M.D., and Thomas Spelsberg, Ph.D. Dr. Goetz is the principle investigator of ongoing studies designed to understand the role of CYP2D6 as a tool to individualize hormonal therapy in the adjuvant setting, and to understand the effect of commonly administered drugs in tamoxifen-treated women. This latter activity is being performed in collaboration with the Consortium of Breast Cancer Pharmacogenomics (COBRA).


About the Gifts That Give More™

Contributions to the Endowed Fund for The Breast Cancer Site Researcher at Mayo Clinic are made through our secure online store by clicking here: Endowed Fund for The Breast Cancer Site Researcher at Mayo Clinic. Choose to contribute $25, $50, $100, or $250 towards the fund. Contributions are matched 100% by Mayo Clinic, up to the first $250,000.

Contributions to the The University of Michigan's Comprehensive Cancer Center can be made through our secure online store by clicking here: Change The Way We Fight Cancer. Choose to contribute $5, $10, $25, or $100 toward the care center's research.

Upon purchase, you will receive an automated e-mail with a link to a full-color certificate of acknowledgment that you may print and frame for display or gift-giving. Adobe Acrobat Reader, or equivalent .pdf viewing program, is required to open the file. The certificate makes a great "instant" gift for an honored colleague, family member or friend.

Contributions are tax-deductible in the U.S.A., and contributers will receive a receipt from GreaterGood.org for their taxes. 100% of the gift goes to fund The Breast Cancer Site Endowed Fund for Breast Cancer Research at the Mayo Clinic, as a grant through GreaterGood.org. GreaterGood stores do not receive any profit from the sale of this Gift That Gives Moretm; we bring it to you in the spirit of the greater good.

Thank You!


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